Similar to nearly all oral anabolic steroids oxandrolone's half-life is quite short with frequent doses of the drug being needed to be taken to ensure that blood levels remain fairly constant. Oxandrolone is relatively quick to be metabolized by the body with concentrations of the drug falling rapidly after ten to eighteen hours after administration3 . This would indicate that at least two doses should be taken per day so that blood levels of the compound remain stable and that no major flucuations occur.
The majority of first time male users of oxandrolone tend to take doses ranging from 40mg to 80mg per day, as reported anecdotally. Experienced users have reportedly used doses up to 150mg per day or more. As is the case with most anabolic steroids, as one increases the doses one also increases the chances of developing negative side effects.
Due to the relatively mild nature of the drug, oxandrolone is also a favorite of women. Doses as low as 5mg per day have reportedly produced dramatic muscle growth and hardness1 . However as with most compounds doses far larger have also been used with varying degrees of success.
As discussed later, due to the unique nature of oxandrolone and it's relatively mild nature in terms of hepatotoxicity, this compound can be run far longer than other 17 alpha alkylated oral steroids. Cycles of the compound lasting ten to twelve weeks are not uncommon, with some users extending their cycles of the drug further. Of course, risks still remain. They are however less substantial than if a user was administering a more toxic compound.
Oxandrolone does not aromatize or convert to DHT and therefore hair loss should not be a concern with this compound. It causes little or no virilization properties, somewhat surprising since oxandrolone does not aromatize either. This of course is one of the major reasons why this steroid is so popular with female athletes.
If used without stacking it with testosterone, oxandrolone can lead to a loss of libido in males as it will shut down your HPTA. However, some users indicate that no libido problems occur. As usual, it varies from individual to individual.
Liver enzymes will likely rise while a user is taking this compound, however the actual damage that occurs to the liver is very minor to non-existent. As noted by William Llewellyn in Anabolics 2004, "One study comparing the effects of oxandrolone to other agents including as methyltestosterone, norethandrolone, fluoxymesterone and methAndriol clearly supports this notion. Here it was demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention among all the alkylated orals tested. 20mg of oxandrolone in fact produced 72% less BSP retention than an equal dosage of fluoxyrnesterone, which is a considerable difference being that they possess the same liver-toxic alteration".
This would seem to indicate, as stated earlier, that oxandrolone can be run safely for longer periods of time than most other 17 alpha alkylated oral steroids. However, liver damage is still a possibility and precautions should be taken. Also, Oxandrolone has been shown to have a negative effect on users' blood lipid profiles, another indication that long terms use of the compound should be avoided4 .
- Llewellyn, William, Anabolics 2004, 2003-4, Molecular Nutrition, pp.76-8
- Demling RH, Orgill DP., The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury., J Crit Care 2000 Mar;15(1):12-7
- Short-term oxandrolone administration stimulated net protein synthesis in young men. Sheffeild-Moore et al. J Clin Endocrinol Metab 84(8) 2705-11 (1999)
- Effects of Oxandrolone on Plasma Lipoproteins and the Intravenous Fat Tolerance in Man. Atherosclerosis 19: 337-46, 1974