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Q: Can Nolvadex (Tamoxifene) and Arimidex (Anastrozole) be used

There is a lot of confusing information on wether or not these two compounds can be ran together. Looking at drug interaction charts, Medscape has the following:

tamoxifen + anastrozole
tamoxifen decreases levels of anastrozole by unspecified interaction mechanism. High likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available. Never use combination. Anastrozole and tamoxifen should not be administered together.

This information has been contradited by a few studies.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362190/

In conclusion, the results of this study confirm that anastrozole does not affect the pharmacokinetics of tamoxifen when the two drugs are given in combination to post-menopausal women with early breast cancer. In addition, the oestradiol suppressant effects of anastrozole appear unaffected by tamoxifen.

As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together.

A: Taking arimidex with tamoxifen decreases the serum concentration of anastrozole by 27%, but has no effect on the pharmacodynamics of either

Q: Does Aromasin need to be taken with fat?

A: It works better when taken with a high fatty meal, yes.

http://www.rxlist.com/aromasin-drug.htm

Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water.

http://www.rxlist.com/aromasin-drug/indications-dosage.htm

The recommended dose of AROMASIN is 50 mg once daily after a meal.

http://www.drugs.com/monograph/aromasin.html

High-fat meal increases plasma exemestane concentrations by approximately 40%.

http://www.drugs.com/monograph/aromasin.html

Dosages >25 mg daily not shown to provide substantially greater suppression of plasma estrogens but may increase adverse effects.

18.08.2020