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GHRP-2 is a growth hormone secretagogue, very similar to GHRP-6, but still different in some respects, differences that make it more attractive to bodybuilders and athletes.
GHRP-2 is a growth hormone secretagogue. This means that it stimulates the body to release growth hormone. GHRP-2 is a synthetic moiety analog. Like ghrelin, it stimulates the secretion of somatotropes from the anterior pituitary gland. Like ghrelin, it is synergistic with the endogenous hormone (secreted by the body) called GHRH (the hormone that releases growth hormone) but also with the synthetic variants of GHRH such as Geref or GRF (1-29).
While GHRP-2 and other synthetic ghrelin analogues increase growth hormone release by inhibiting somatostatin, GHRH increases growth hormone production by other means. That is why such preparations work so well together.
Unlike ghrelin, GHRP-2 is not lipogenic, which means it does not promote fat retention. While ghrelin plays an important role in inducing hunger, GHRP-2, as its analogue, does not significantly increase appetite.
GHRP-2 is synergistic with GHRH due to their secondary actions on hypothalamic neurons. The level of growth hormone secreted when co-administered GHRP-2 and GHRH is higher than if each of the two preparations were administered alone.
Neuronal excitation in the hypothalamus lasts about one hour after GHRP-2 administration, rapidly causing massive growth hormone secretion, which gradually fades, 3 hours after the drug is administered. This release of growth hormone resembles the body's natural secretion, and in many ways is superior to the administration of synthetic HGH, which has an eight-hour lifespan. Cell desensitization is more likely to occur when the growth hormone is longer in circulation.
The decline in natural growth hormone production, which occurs with aging, is not a consequence of the inability to produce growth hormone, but rather a poor signal to start production. The pituitary gland of older people can produce the same amount of growth hormone, with the same frequency as in young people, but the starting elements, ghrelin and endogenous GHRH, are released in much smaller quantities compared to a young person or without medical problems. Therefore, GHRP-2 is equally effective in older people.
GHRP-2 has a protective effect on the liver and also has anti-inflammatory effects; it seems that IGF-1 production may also increase.
The optimal dose of GHRP-2 is 1 mcg / Kg body, but most bodybuilders will administer 100 mcg. The administration is done by subcutaneous injections, twice a day: 100 mcg in the morning and 100 mcg in the evening; 3 administrations per day can be done. After and before administration, nothing is eaten for 30 minutes.
The results are really visible when GHRP-2 (or any preparation in this class, such as GHRP-6 - a very similar preparation, but reported to induce a greater hunger sensation) is combined with a GHRH (Geref , e.g). The two preparations are administered concurrently, due to the mode of action. When GHRP-2 is administered, a pituitary gland pulse is given, a signal that causes it to release much growth hormone. GHRH further increases this pulse by applying it. Taken alone, GHRH has very little impact on growth hormone secretion. The two preparations are combined in equal doses (100 mcg of GHRP-2 and 100 mcg of GHRH).
This combination creates a three-hour pulse, equivalent to 8 U.I. of synthetic HGH.
Due to the lower cost (production is much cheaper than HGH) and much less possible side effects (the most common side effect is joint pain) peptides such as GHRP-2 may soon replace synthetic growth hormone.