Human chorionic gonadotropin is used during steroid regimens to prevent testicular atrophy and total inhibition of testosterone secretion.
Active substance: human chorionic gonadotropin
Trade names: Biogonadyl, Choron 10, Chorulon, Ecklut, Gonadotraphon LH, HCG, Pregnyl, Primogonyl, Profasi, Ovogest
Human chorionic gonadotropin is a hormone found only in the placenta of pregnant women. For women it has no significant role, but for athletes it has some very interesting features. It can mimic the luteinizing hormone (HL), secreted by the pituitary gland, which is the signal of testosterone production. Sex hormones act through negative feedback, when they are present in too high amounts (such as androgen or estrogen steroids) a signal is sent to the brain to stop the secretion of HL. During long-term steroid cycles, if your own testosterone secretion is too long suppressed, the testicles will begin to atrophy until they lose their functionality. By administering a hormone similar to the luteinizing agent, the function of the testicles and their return to normal size can be restored.
Because it produces some accumulation of testosterone in the body, it may also have certain anabolic properties, but less significant. Therefore it is not used by athletes for this purpose.
HCG is used for medical purposes to induce ovulation or to treat ovarian dysfunction in women, or to stimulate testes that do not produce enough testosterone in men. It is also used to treat testicles that have not descended into the scrotum, in children or adolescents. For athletes it has no practical application, but for athletes who use anabolic and androgenic steroids it is very useful. As I said before, HCG is similar to the luteinizing hormone, which stimulates the testes to secrete testosterone. It is especially useful during very long steroid cycles, or when using very high doses. In such situations, the hypothalamus no longer signals the testes to produce testosterone, and the phenomenon of testicular atrophy occurs (it shrinks). The use of HCG will send a synthetic signal, similar to that sent by LH, and so the testicles will continue to produce testosterone, and atrophy will be avoided to a greater or lesser extent. Not only does it help maintain the size and function of the testicles, it also helps bring them back to normal if they have shrunk. Especially when androgen levels are below the limit (due to steroids), which could have unwanted consequences. Restoring normal testosterone production as quickly as possible is crucial when completing a steroid treatment. The price paid if these levels are not restored, is the loss of the great part of the gained muscle mass, the main reason being cortisol. Cortisol sends a signal to the muscles, which is opposite to that of testosterone. If the cortisol problem is not resolved (due to very low testosterone levels) it will quickly devour muscle mass gained during the steroid cycle.
Testicular atrophy can be easily prevented with the help of HCG. But for this it needs to be given in small doses throughout the steroid cycle. Unfortunately, many steroid users still believe that HCG is used after the cycle ends, as part of post-cycle therapy. But if HCG is given during steroid treatment, recovery is faster and better.
Many HCG recommendations for steroid users suggest the use of high doses of 2500-5000 U.I. once or twice per week. The doses are inspired by studies from the 1960s, which were used in men with reduced testicular function due to a long deficiency of luteinizing hormone. A large period of absence of HL severely desensitizes the testes, requiring high doses to sensitize them. In men with normal testicular sensitivity, the maximum increase in testosterone production is seen from doses of 250 U.I., with minimal increases to doses of 500 U.I. and even from doses of 5000 U.I.
If you do a whole cycle of steroids without using Pregnyl then higher doses are required to get your testicles back on your feet, but there is a cost to that and you may not fully regain your testicular functions.
An important thing to understand is the secretion ability of testosterone which is synonymous with testicular sensitivity. It is about how much testosterone can produce the testicles when exposed to any amount of luteinizing hormone or HCG. to produce the same results as when you have a normal sensitivity. If you lose too much testosterone secretion capacity, no dose of HL or HCG will trigger testosterone production anymore - and this leads to a small production of testosterone that is permanent.
To give you an idea of how quickly you can desensitize your testicles from an average steroid cycle, consider this: Luteinizing hormone levels drop rapidly from the day after steroid administration begins. By desensitizing the testicles to HL for 12-16 weeks the volume of Leydig cells decreases by 90%, the insulin factor 3 by 95% and the intra-testicular testosterone production by 94%. All of these factors are very important for total testosterone production, which can drop by 98%.
Visual evaluation of the testicles is not necessarily an effective method of judging whether the testicles are desensitized or not, their size is not correlated with the ability to release testosterone. Leydig cells, the main place of testosterone production, occupy only 10% of the testicles, so a 10% reduction in their volume may mean a complete halt to testosterone production.
There are also studies on this topic. One of them was done on power athletes who took steroids for 16 weeks and in the end received 4500 U.I. from HCG. It was found that steroid users were 20 times less sensitive to HCG effects than those who had not used steroids. In other words, their testosterone secretion capacity was drastically reduced due to the lack of the luteinizing hormone for 16 weeks.
Studies on patients using steroids have shown that aggressive HCG protocols, up to 10,000 U.I. at 3 days for 12 weeks they failed to restore the testicles to normal.
Given the above it is obvious that preventive measures must be taken to avoid testicular degradation. Testicular sensitivity must be protected! And as HCG is cheap and easy to obtain, and the administration is not painful, it is easy to use during steroid cycles.
Studies in normal men using steroids have shown that 100 U.I./day of Pregnyl was a sufficient dose to maintain testicular functions, without the desensitization often associated with too high doses of HCG. It is important that these small doses of HCG be started before the testicles reduce the sensitivity of the testicles, which appears rapidly in the first 2-3 weeks of the cycle. Equally important is the discontinuation of Pregnyl 2-3 weeks before starting post-cycle therapy, so that leydig cells can be readjusted to the luteinizing hormone produced by their own body.
The most effective dose of HCG during a steroid treatment would be 250 U.I. from 4 to 4 days. A less recommended alternative is a dose of 500 U.I./week. The HCG half-life is 3-4 days and the luteinizing hormone is 1-2 hours. Therefore, it is advisable to divide the dose of HCG every 4 days for an optimal effect of increasing and decreasing concentrations. But more than 7 days between administrations can increase the desensitization rate to HL or HCG.
If the steroid cycle has started for some time and you want to start HCG, the optimal dose is calculated by multiplying 40 U.I. with the number of days when the luteinizing hormone was not present in the body. For example, if it is 60 days, 40 U.I. x 60 = 2400 U.I. HCG dose. But the maximum daily dose is 5000 U.I. and between administrations should take a break of 4-7 days. High doses require long periods between administrations (for example, a dose of 2500 U.S. = 7 days between injections).
If Pregnyl has been given during the steroid cycle, it is not used in PCT.
Doses of 250 U.I. are used during steroid treatment. from 4 to 4 days, starting at 14 days after the first administration of steroids. At the end of the cycle, HCG is given up two weeks before the start of post-cycle therapy. For example, HCG will be discontinued at about the same time as the last injected testosterone injection. If it is oral steroids, HCG will be discontinued 10 days before the last dose of steroids. Thus the pituitary gland will begin its own secretion of luteinizing hormone. Recovery begins only after HCG has left the body, the body not producing HL for as long as there is HCG in circulation.
The doses of HCG required for each individual may vary. Leptin is a major inhibitor of testicular function, so those with high fat content require higher doses of Pregnyl.
<10%: body fat: 100-300 US / twice a week.
10-15%: body fat: 300-350 US / twice a week.
> 15%: body fat: 350-500 U././ twice a week.
It is given with insulin syringes. After recombination human chorionic gonadotropin is stored in the refrigerator, and is valid for 2-3 weeks, then loses its properties. For low doses, the easiest is to keep in an insulin syringe. Combine 1 ml of solvent with powder and draw in an insulin syringe. Then the dose is calculated based on the concentration. For example, Pregnyl of 5000 U.I. thus recombinant will result in a dose of 500 U.I./ 0.05 ml. If you want to get a lower concentration on a larger amount of liquid injected, simply increase the amount of solvent. In our example, if 2 ml of solvent were used, the same dose of 500 U.I. per 0.1 ml.
The insulin syringe is kept in the refrigerator. At each administration, change the needle with a new one and inject the desired quantity.
Regarding the use of HCG in post-cycle therapy, it is not used concomitantly with Clomid. It can be administered in small and frequent doses, 250-500 U.I. daily, for two to three weeks, immediately after the end of the steroid cycle, or at the end of it. HCG should always be accompanied by Nolvadex, 20 mg, to avoid estrogen-related side effects, especially gynecomastia (especially if high doses of HCG are administered). Small doses of 250 U.I or 500 U.I. decrease the risk of desensitizing the testicles. When it comes to HCG, more clearly is not better. It is best to start from 250 U.I., and if in 5-6 days you do not notice any effect (the testicles do not recover), slightly increase the dose.
HCG cycles should be 2-3 weeks and with a break of at least one month between them. Prolonged use can permanently desensitize the testicles to the luteinizing hormone, which means that the testicles will never produce testosterone again (and you don't want that!). This effect is theoretically possible, but no cases have been registered so far.
Possible side effects are as in the case of anabolic and androgenic steroids, although gynecomastia is the most likely. Water retention may still occur if high doses are used. Gynecomastia can also occur at high doses. Another possible side effect, seriously, is to desensitize the testicles, as I have maintained above. As it mimics the luteninizing hormone, HCG being brought in exogenously, the hypothalamus will no longer secrete this hormone, and the effects may be irreversible. Also, HCG administration should be discontinued two weeks before discontinuation of Nolvadex, otherwise there is a risk of suppressing testosterone secretion itself. This is why HCG is given in the last weeks of the steroid cycle or during the steroid cycle and before the start of post-cycle therapy.
It is widespread on the black market, and counterfeits are rare. Due to the similarity of the packaging and preparation method, it is sometimes used to falsify growth hormone. More about how you can identify if you have purchased growth hormone or HCG on the HGH profile.
HCG comes packaged in two ampoules, one with powder and one with solvent (liquid) for injection. The liquid is extracted (sterile) from the vial and placed in the vial with powder, stirring. It is injected intramuscularly, but not as deep as steroids. It is most often given subcutaneously, with small needles, by insulin; most make their subcutaneous injections into the belly. The prepared HCG should be kept refrigerated. If not prepared, no refrigeration is required, but must be protected from sunlight and maintained at temperatures below 25 degrees Celsius..