IGF-1 Long R3, as it can be inferred from the name, is a synthetic injectable form of insulin-like growth factor 1, used by bodybuilders and spotlights to increase muscle mass.
Trade names: Igtropin, IGF-1 LR3
Insulin-like growth factor 1, from which IGF-1 Long R3 is derived, is a peptide hormone that is naturally found in the body. It belongs to the same family of hormones as insulin. In terms of peptide hormones, IGF-1 is relatively small, having a chain of 70 amino acids. But this has no relevance in its biological importance. IGF-1 is the anabolic mediator of human growth hormone (HGH), which by itself has no anabolic effect. The ability of HGH to stimulate IGF-1 secretion makes it such an potent anabolic agent. The hormone IGF-1 was discovered in 1957. It was initially thought to aid cartilage regeneration. It was not until the late 1970s that the name IGF-1 was adopted and its effects began to be studied.
IGF-1 promotes development in almost all tissues. Not only the muscles but also the internal organs, brain and eyes. Because muscles are made to respond to external stimuli by increasing and increasing strength, they are more receptive to IGF-1 than the rest of the organs. Although IGF-1 promotes anabolism throughout the body, it cannot be said that it is dangerous to be used to increase muscle mass (but the danger of increasing internal organs cannot be ignored).
IGF-1 assists in better muscle cell activity and a better concentration of protein in muscles. Human growth hormone and IGF-1 are potent hormones that manifest their anabolic properties differently from anabolic steroids. They are seen more as substances that stimulate hyperplasia (increase of cell number). IGF-1 produces muscle growth through viable and qualitative growth, not by increasing the volume of muscle cells.
Initially there were some problems with the administration of IGF-1 as a therapeutic method. The main problem was its metabolism rate, with two injections a day required to maintain a constant blood level. The same problem occurred at the beginning of steroids, except that testosterone has a longer life span than IGF-1 in the blood. Scientists have had to look for new ways to increase the half-life before it can be used. This required synthetic modifications to IGF-1. A popular form of such IGF-1 is this, IGF-1 Long R3 or LR3-IGF-1. It has a longer half-life than insulin and is missed 2.5-3 times more potent than normal IGF-1.
IGF-1 Long R3 is currently produced by Australian company GroPep, which holds the patent for this unique form of IGF-1. It is still in the experimental medicine phase, but it could still be purchased by bodybuilders, through international distributors who sell to universities for experiments. It costs between 170 and 400 dollars per milliliter, having a purity of 85%.
They are found in powder form or diluted in an alcohol solvent. If it is like powder, it should be mixed with alcohol solvent for storage and diluted with distilled water or bacteriostatic water before administration. The injection is done with sergeants used in the injection of insulin. It is recommended to be kept refrigerated.
IGF-1 Long R3 is also called IGtropin, produced by the Chinese company GenSci. It is supposed to be the same compound as the one produced by GroPed, but it is not known whether they obtained the raw material through an agreement with it. The feedback from the product was positive, which shows that regardless of the source of supply it offers a quality IGF-1 Long R3. It is however more expensive, jumping from $ 500 per milligram. The higher price is offset by the fact that it comes in an easier to use form, each kit containing 10 ampoules with 100 mcg of hormone in each, and another 10 ampoules with sterile substance in which the hormones had to be diluted.
Unlike subcutaneous HGH, IGF-1 Long R3 injection is intramuscular. Although subcutaneous injections are also possible in this product, they give more discomfort than intramuscular ones. It is good to inject yourself into the muscle group trained that day, in an effort to stimulate local growth.
The dose is usually between 20 mcg and 80 mcg, with administration taking place daily. The daily dose can be divided into two, at distances of 10-12 hours. Some bodybuilders also venture at doses greater than 100 mcg per day, and it is said that some top professional bodybuilders use even over 200 mcg per day during periods of muscle mass accumulation. But considering the astronomical costs that such practices would bring, it is more likely to be mere rumors. Among amateur bodybuilders, the daily dose is 30 mcg, which allows a 1 milligram vial to reach for a month.
The results obtained with the administration of IGF-1 Long R3 are better pumping, increased appetite, gain of smooth muscular mass and strength and stimulation of thermogenesis (fat loss). A 30-day cycle earns an average of 2-3 kilograms of muscular mass. Some bodybuilders have claimed that they also gained 6-8 kg using only IGF-1 Long R3 in 4-week cycles. However, given alone, it is not as effective as steroids, but it is powerful enough for a non-steroidal anabolic substance. Also keeping the muscle mass gained after the cycle ends is very high, which cannot be said when it comes to steroids. This is due to several factors, including the lack of hormonal crash.
When it comes to definition, IGF-1 Long R3 is not as effective as human growth hormone. But that does not mean that IGF-1 has no value in this regard. Those who use it have reported that it has a quite pronounced fat reduction effect. It seems to allow the fat layer to be under control even when large amounts of calories are ingested. It seems that it helps to reduce the depositional stratum in mass phases, but this aspect is related to the metabolism of each individual. So we can say that IGF-1 is not the best method of detection but it is a component that can be successfully added to such a cycle.
The length of cycles with IGF-1 Long R3 is between 4 and 12 weeks, after which a break of at least 4-6 weeks is made.
It should not be forgotten that there are risks associated with the use of IGF-1 Long R3. Increased internal organs, thinning of bones and skin, insulin resistance, hypoglycemia, water retention and edema, and even gynecomastia in those who are very sensitive. There were even reports of carpal tunnel syndrome, which is usually preceded by the numbness of the hands and wrists. It is a substance that must be respected and not abused. I would like to point out that it is still an experimental drug, and the effects on humans have not yet been fully discovered. Its use will transform it to some extent into a human guinea pig.
The fact that it is not approved in any country has not stopped the athletes from using it, especially considering the beneficial effects it can bring. That is why it was introduced relatively quickly on the black market. Although not abundant, it is not impossible to obtain. Those who have used it refer to it as "super HGH", which is not far from the truth. With the administration of IGF-1 Long R3, we can enjoy the effects of this hormone, without relying on the body's ability to produce it when stimulated by HGH. An analogy can be made between the use of HCG to stimulate testosterone secretion and the direct administration of testosterone such as cytopioned testosterone, for example. So we see why the popularity of this hormone has grown so much lately and from now on we can expect an even greater spread of it.