CJC-1295 is part of the new wave of hormonal peptides used in sports to increase sports performance. These are powerful substances, but they do not have such dangerous side effects as synthetic growth hormone. CJC-1295 is a hormone that releases growth hormone.
CJC-1295 is a growth hormone releasing hormone (GHRH). The best known GHRH is sermorelin, or Geref. These peptides are used medically to stimulate the pituitary gland to release growth hormone. They are very popular in the anti-aging world, with the ability to reverse some aging processes. It is known that growth hormone strengthens cardiovascular and immune systems, strengthens and mineralizes bone tissue, promotes protein synthesis and promotes fat burning for energy.
As bodybuilders use synthetic growth hormone to burn fat and build smooth muscle tissue, these peptides have begun to become very popular in this sport as well as in other sports. The administration of synthetic HGH can have negative effects, while the administration of peptides that stimulate the body's own secretion is much safer.
The pituitary gland releases growth hormone through pulsation. It is capable of rapidly producing large amounts of growth hormone, which it stores, both in finite and incomplete form. In adults, pulses that completely empty these reserves are rare. It happens especially in children, who need to grow up. As we age the pituitary DO NOT lose its ability to store and release growth hormone; rather, we experience a reduced ability to train the gland to release growth hormone.
The administration of HGH is more inefficient than its own secretion by pulsation, due to physiological events that occur at the cellular level, when there is too much growth hormone in the body. Let's say that it is preferable to have several pulses throughout the day of growth hormone, which cannot be achieved by the administration of HGH.
Here comes the hormone that releases growth hormone. The administration of GHRH will create a growth hormone pulse, the pulse being small if it is administered when there is no natural pulsation of the pituitary gland, and larger if it is administered along with a natural pulsation of the pituitary gland. Because of this, these products are always used with GHRP (growth hormone-releasing peptides - for example GHRP-2), capable of creating single, much stronger and more constant pulses. Their effect is synergistic, not cumulative. This means that if we assign the value 2 to a GHRH and the value 5 to a GHRP, since it concerns the ability to release growth hormone, administered concomitantly, the result will not be 5 + 2 = 7, but rather 5 + 2 = 10 or more. .
GHRH is available in several forms, the only difference being the half-life. The hormone that releases naturally growing hormone is made up of 44 amino acid peptides, of which the first 29 are active ones. A shorter synthetic version was created, containing only the 29 amino acids, identical in action and half-life with the natural counterpart. It was called growth hormone release factor or GRF (1-29). It is known mainly as Geref or Sermorelin. The problem is its half-life, measured in minutes.
In order to improve its stability and half-life, it made some structural changes (4 in number) and thus the half-life was increased to over 30 minutes. It's called tatraubtitu GRF (1-29) or modified GRF (1-29). Another name under which it can be found is CJC-1295 without DAC (Drug Affinity Complex).
And I reached the final and at CJC-1295. In trying to create a more stable and longer-acting GHRH, CJC-1295 was created. It is identical to the modified GRF (1-29) mentioned above, with the difference that it is added to the amino acid lysine, which binds to a non-peptide molecule called DAC (Drug Affinity Complex). Thus, CJC-1295 can bind to albumin after injection, which extends its life to a few days.
The CJC-1295 is difficult to produce and costs are high. From here and the high price with which it is sold, which makes it avoided by many users, preferring the form without DAC, ie GRF (1-29) muffled, which is sold at a price ten times lower.
The effective dose of CJC-1295 without DAC is 100 mcg, 1-2 times daily, concurrently with a GHRP, as GHRP-2 have GHRP-6, in doses of 100-200 mcg. For CJC-1295 with DAC, the dose is 2 mg per week, due to the very long life expectancy. The doses of GHRP (if used) remain 100-200 mcg, 1-2 times daily.
In the case of CJC-1295 without DAC, you should not eat at all carbohydrates or fats 2 hours before administration and half an hour after administration. They stimulate the release of insulin, which inhibits growth hormone. If you use a GHRP concurrently, these precautions are not required. The rule of not eating carbohydrates and fats does not apply to CJC-1295 with DAC due to the long life.
In general, hormonal peptides such as GHRH or GHRP have no major side effects. In the case of CJC-1295 with DAC, things are not so. Side effects are: edema (accumulation of water in the tissues), inflammation of the joints, lethargy, feelings of sadness, carpal tunnel syndrome, high levels of glucose in the morning, on an empty stomach and sometimes high blood pressure.
Therefore, the best choice is CJC-1295 without DAC, having a decent half-life (30+ minutes), far superior to other GHRH, such as Geref. In addition, the risks of adverse effects are minimal, usually being related to the injection site, which can be irritated.
Both CJC-1295 with DAC and without DAC are administered subcutaneously. They come in powder form, which is combined with bacteriostatic water. Depending on how much water you use, the amount is in mcg / ml