Post-cycle therapy (PCT)
Post-cycle therapy (PCT) is of extreme importance. As its name suggests, it involves restoring endogenous testosterone levels after a steroid cycle. Those who ignore it risk losing everything they have earned while on steroids, even more so. Worse, in some cases the body may remain hormonal imbalance. So, never ignore post-cycle therapy
As the saying goes: "there is a price for everything", and in the case of the use of steroids this price consists of the decrease of the production of own hormones (at least temporarily). What happens is quite simple; when you take steroids, the body stops producing it alone. After cessation of use, the body will no longer produce testosterone for a period. This interval is very disturbing, because there will be nothing present to stop the catabolism and until the oranganism returns and begins to produce testosterone alone, most of the gains during the cycle may be lost. In order to maintain your accumulated muscle mass you must do so in such a way that the body begins to produce its own testosterone as quickly as possible. How you can do this differs from person to person. Without understanding what is going on in your body and why certain compounds help to remedy the situation, it is difficult to choose an optimal post-cycle therapy for you.
HPTA (hypothalamus-pituitary-testicular axis)
HPTA is like a thermostat for the body of natural testosterone production. Too much testosterone and the "blast furnace" will stop. Too little testosterone and the temperature is high. This process has three levels.
At the top is the hypothalamus that releases GnRH (the gonadotropin-releasing hormone) when it feels like a lower testosterone level. GnRH sends a signal to the second level of the axis, the pituitary gland, which responds by releasing LH (luteinizing hormone), which in turn stimulates the testes to release testosterone. The same sex hormones (testosterone and estrogen), through negative feedback, help stabilize levels when too much testosterone is present in the body.
Synthetic steroids can send the same negative feedback.
Post-cycle therapy (PCT) involves the use of drugs that by various mechanisms help restore hormonal balance after the end of a cycle in which anabolic and androgenic steroids have been used.
Clomiphene citrate, known mainly as Clomid, and tamoxifen, known as Nolvadex, can be used post-cycle to restore natural testosterone production. As both drugs have the ability to block estrogen from acting on the hypothalamus and pituitary gland, thus stopping negative feedback, it can be said that these two substances increase FSH (follicle stimulating hormone) and LH in the body. Increased LH stimulates Leydig cells in the testes, leading to testosterone production.
There are people who find it sufficient to use only tamoxifen, after a cure of anabolic and androgenic steroids, so that testosterone levels return to normal. But most of them prefer to use both drugs to attack the problem from all angles. It should be noted that tamoxifen is more effective in stimulating LH secretion, while comparing milligrams per milligrams with clomiphene citrate. Also, Clomid may bring with it some side effects such as visual disturbances and sudden mood swings
When we look at the methods by which both substances increase testosterone depletion, it becomes clear that some methods used in the past are wrong. Many users will use Clomid in the middle of the cycle, hoping it will increase testosterone production, to minimize overall stagnation by the end of the cycle. But the only effective use of Clomid in the middle of a steroid cycle, especially if high-suppressive substances are used, is anti-estrogen. Therefore, if androgen levels in the blood are increased, Clomid will not do much to restart testosterone production. It is effective to start post-cycle therapy after androgen levels in the blood caused by steroids have decreased sufficiently; and this depends on the half-life of the steroids used.
Due to the half-lives of Clomid and Nolvadex, it is not necessary to divide the doses throughout the day, take them when it is more convenient.
Tamoxifen doses for PCT:
Day 1 100 mg
Next 10 days 60 mg
The next 10 days 40 mg
Above is an example of how tamoxifen can be used. Cycle duration, steroids used and other parameters may change the structure and duration of this protocol. For increased efficiency, combine Clomid and Nolvadex.
Doses of tamoxifen and Clomid for PCT:
Day 1 clomid 250 mg + tamoxifen 60 mg
Next 10 days clomid 100 mg + tamoxifen 40 mg
Next 10 days clomid 50 mg + tamoxifen 20 mg
This method should be effective. With regard to the use of tamoxifen only, in the case of stronger cycles, it may be necessary to require higher doses and longer periods of time to achieve its effect.
When starting PCT, it depends on the steroids used in the cycle. If more anabolic steroids are used, it is the starting point of the post cycle therapy and its duration, the one that has the longest time. That's not to start PCT when we still have high androgen levels in the body.
Below is a list of the most popular steroids:
Steroid When starting PCT, after the last administration Duration PCT
Testosterone Enantat 2 weeks 3 weeks
Chopped testosterone 2 weeks 3 weeks
Testosterone Propionate 3 days 3 weeks
Testosterone Suspension 6-8 hours 3 weeks
Sustanon 18 days 3 weeks
Winstrol 12 hours 2/3 weeks
Dianabol 8-10 hours 3 weeks
Trenbolone 3 days 4 weeks
Deca-durabolin 3 weeks 4 weeks
Primobolan Depot 14 days 2 weeks
Anavar 8-10 days 2 weeks
Equipoise 3 weeks 4 weeks
Masteron 3 days 2/3 weeks
Anapolon 24 hours 3 weeks
Turanabol 24 hours 3 weeks
Nebido 16.5 days 3 weeks
HCG (Pregnyl), or human chorionic gonadotropin, is a peptide hormone that can be useful to those who suffer from testicular atrophy during a steroid cycle.
In the past it was used in post-cycle therapy (and still used by many), in the belief that it will restore testosterone production; but this is not true, because of its mechanism of action. This drug mimics the action of LH by stimulating Leydig cells in the testes to produce testosterone. This is useful for rectifying, or preventing, testicular atrophy during a cycle. But it will not help the process of restoring testosterone production in post-cycle therapy. This is because HCG will bring increased levels of estrogen into the body, due to the aromatization of testosterone produced by the testes. And this will lead to further suppression of the HPTA axis.
It is more useful to use HCG within two weeks, given in small doses; this to reduce the side effects and give more fruitful results. Usually, administration of HCG is accompanied by 20-40 mg of tamoxifen to prevent estrogenic side effects. 500-1000 U.I., administered over a period of two weeks, in small doses and equally divided, are sufficient to benefit from the positive effects without too great negative flavoring effects. Even more effective is the administration of HCG in small doses during the steroid cycle.