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TAMOXIFEN

TAMOXIFEN
Nolvadex is the most known, accessible and used anti-estrogen. It is efficient, easy to find and has a low price. Even though there are far superior preparations, it has remained in the top of bodybuilders' preferences and those who use anabolic steroids because it does its job, and usually has no noticeable side effects.
 
Active substance: tamoxifen
Trade name: Tamoxifen, Nolvadex
Nolvadex is one of the most accessible anti-estrogens. It is part of the SERM anti-estrogen category, selective estrogen receptor modulators, and has both agonistic and antagonistic estrogen characteristics. In other words, it can act as estrogen in some tissues (more specifically liver), and block the above action of the so-called hormone in others. In breast tissue it is a powerful antiestrogen, so it is used to treat breast cancer in women. It is sometimes used even as a preventive method, being used by women with a history of breast cancer in the family.
In the case of bodybuilders and athletes, tamoxifen citrate is used to counteract the side effects of estrogen caused by the use of certain anabolic and androgenic steroids. It is also used after the end of a steroid cycle, in post-cycle therapy, to restore the testosterone production.
The main cause of concern among bodybuilders and athletes is gynecomastia, the development of the female breast test in men. The first signs of gynecomastia are small swelling under the nipples; if they are allowed to evolve, they can be transformed into solid tissue of considerable size, which can only be treated surgically.
Nolvadex blocks the action of estrogen in breast tissue. It does this by binding to estrogen receptors, so estrogen can no longer exert its action. This property makes it useful in the treatment of breast cancer (tumors feed on estrogen - if it cannot be attacked by them, they die) and in the prevention of gynecomastia.
In patients with breast cancer Arimidex is mainly used for treatment, and after the tumor disappears it is passed on to tamoxifen to prevent relapse.
Another unwanted effect of estrogen is water retention, which leads to muscle coverage, and the disappearance of definition. Also, fat accumulation may occur, but it is more of a diet. To prevent all these side effects, Nolvadex can be used during a treatment with steroids that are flavored (turns into estrogen), but the effects of reducing water retention are not very satisfactory. If the priority is the definition, then stronger antiestrogens, such as Arimidex, are used.
In fact, most athletes use flavoring inhibitors such as Arimidex during cycles and keep Nolvadex for PCT. However, flavoring inhibitors can have negative effects on cholesterol, so the first option is to stay tamoxifen and switch to flavoring inhibitors only if water retention becomes problematic.
Another ability of tamoxifen is that it helps to increase FSH (follicle stimulating hormone) and LH (luteinizing hormone). It does this by blocking the negative feedback caused by estrogen, in the hypothalamus and pituitary gland. It is similar to the action of Clomid and Cyclophenyl.
Precisely for this ability, tamoxifen is used at the end of a steroid treatment to restore normal testosterone production in post-cycle therapy.
In the liver, Nolvadex acts like estrogen, which is good, because it helps regulate serum cholesterol by promoting good cholesterol (HDL) and reducing bad cholesterol (LDL). So it is preferable to use Nolvadex during a steroid treatment to prevent gynecomastia, than other stronger antiestrogens such as Aromasin, for example. But in the case of high doses of steroids, tamoxifen improves serum cholesterol by several percent, and cannot completely prevent the adverse cardiovascular effects.
Some athletes claim that it diminishes the anabolic effect of steroids to some extent. This is possible because it reduces the secretion of insulin factor IGF-1, but to a small extent.
Side effects of tamoxifen
There are side effects associated with tamoxifen, but in general it is a highly tolerated selective modulator of estrogen receptors, both for women and men. Side effects may occur somewhat more frequently in women than in men. This includes:
     vaginal discharge
     flushes
     upset stomach
     headaches
These are the most common side effects of tamoxifen. Other rarer side effects are:
     hives
     decrease of white blood cells
     endometrial changes
     increased triglyceride levels
     pulmonary embolism
These side effects are possible, but very rare. It should be mentioned that pregnant women or pregnant women are not allowed to become pregnant.
Tamoxifen administration
In the case of easily flavored steroids, the optimal effect is obtained by combining Nolvadex or Proviron. A daily dose of 10-30 mg of Nolvadex and 25-30 mg of Proviron virtually completely protects the body from unwanted estrogen accumulation.
The only standard dose used is 20 mg daily. If this dose does not protect the gynecomastia athlete it is advisable to use a flavoring inhibitor (Arimidex for example). If water retention becomes problematic, a flavoring inhibitor is also used. But often water retention is related to diet and too much carbohydrate and calorie intake. If the athlete has a balanced diet and a healthy lifestyle, 20-30 mg / day of Nolvadex is enough to control estrogen during steroid cycles. Exceptions are very heavy steroid cycles, but they are used mostly by elite athletes.
A certain amount of estrogen is needed in the body, and a complete blockage of it can lead to side effects such as decreased libido, depression and poor mood.
Nolvadex is given when needed, precisely so as not to interfere with the mass accumulation effect of steroids. Some people do not need anti-estrogen during a steroid treatment, even if they are easily flavored steroids; other people are more sensitive, and also experience negative estrogenic effects when using Deca-durabolin or Equipoise (steroids that are known for their low estrogen effect). There are several factors that cause the appearance of these side effects, such as age and a high percentage of body fat (adipose tissue is one of the main flavoring sites).

11.12.2019