Propionate testosterone is the shortest ester of synthetic testosterone, having rapid action. This injectable compound has a slower rate of release from non-esterified testosterone, but much faster than all other forms of esterified testosterone. It was synthesized for the first time in 1935, shortly after appearing on the market and the first product containing testosterone propionate ester, being marketed under the brand name Testoviron, which remains a popular choice among users to this day.
When testosterone was first synthesized, it was in its pure, non-esterified form. The advantage of this compound was that it is a very fast acting compound, the steroid levels reaching maximum levels shortly after administration. However, this was the disadvantage of non-esterified testosterone as well, requiring very frequent administration. In this sense, to solve the problem, testosterone was attached to propionate ester, being a short ester. Once the propionate testosterone reaches the bloodstream, the enzymes in the body work to break the link between propionate ester and testosterone, ultimately eliminating propionate altogether, which remains pure, non-esterified testosterone, which is free to do its job in the body. If the half-life of non-esterified testosterone is 2-4 hours, when attaching the propionate ester to the compound, the half-life can be extended up to 4 and a half days.
Testosterone propionate should be injected daily, so that blood levels do not fluctuate too much, or at least once every 2 days. The frequency of injection of this steroid is the main disadvantage and the reason why many people are scared of its use, choosing other forms of testosterone, such as toned or chipped testosterone, which allow for a poorer administration.
Testosterone has the role of promoting nitrogen retention in muscle. The more muscle the nitrogen contains, the more protein it can synthesize in the muscles. On the other hand, testosterone also increases levels of insulin-like growth factor 1 (IGF-1), whose role is to coordinate body growth and metabolism. It also increases protein synthesis and increases the number of red cells, also inhibiting glucocorticoid hormones.
Since testosterone is the hormone in relation to which all other anabolic steroids are defined, it has a 100% anabolic ratio and a 100% androgenic ratio.
What is Propionate Testosterone Used for?
Testosterone propionate is used in medicine in the treatment of recovery, in the treatment of androgen deficiency in men, andropause or hypogonadism, in the treatment of sexual dysfunction, menopause, endometriosis, or chronic uterine blood dysfunction (menorrhagia).
On the other hand, it is also used by athletes in performance sports, to increase athletic capacity, muscle mass and the body's ability to recover from effort.
The most common use of propionate testosterone is for those who suffer from low natural testosterone production. Low levels in men of testosterone in the blood are associated with loss of libido, erectile dysfunction, loss of strength, power and muscle mass, increased body fat, loss of mental clarity and ability to concentrate, lethargy, insomnia, depression, levels low in energy and, last but not least, a much weakened immune system. If you suffer from these symptoms, we recommend that you consult an endocrinologist as soon as possible, who will perform the necessary research and will tell you if you should be on a testosterone replacement therapy or not.
Positive effects of using Testosterone Propionate:
If you suffer from the symptoms listed above of a low level of testosterone in your blood, starting to use propionate testosterone means the end of these problems for you. On the other hand, it increases endurance to the effort, strength and time required to recover from the effort, helping to increase muscle mass and to lose body fat.
Other positive effects of testosterone propionate administration are: increased collagen synthesis and bone mineral content, increased self-esteem, increased levels of IGF-1 and MFG, increased hemoglobin and anti-catabolic action on muscle tissue.
1. Negative effects of estrogenic nature:
These lie in the ability of testosterone to convert into estrogen in the body, a process that bears the name of aromatization, taking place under the influence of an enzyme called the aromatase enzyme. Too high levels of estrogen can lead to gynecomastia or excessive water retention, ultimately leading to increased blood pressure. The estrogenic effects are, however, quite easy to control, if we use anti-estrogenic drugs, which can be selective estrogen receptor modulators (eg Nolvadex, also known as tamoxifen), or aromatase inhibitors (eg Arimidex).
2.Negative effects of androgenic nature:
Being a potent androgenic steroid, the androgenic adverse effects can occur in those prone and include the appearance of acne, hair loss (especially for those prone to baldness), thickening of the voice, oily skin and excessive hair growth on the body. In some people, aggression may also occur, although it is not popular among users of this steroid, as it is, after all, the hormone that the body naturally produces in quite large doses, in normal people. High doses can, however, lead to increased levels of aggression, especially when combined with other highly androgenic steroids.
3.Negative effects on the cardiovascular system:
Testosterone propionate can lower positive cholesterol (HDL) levels by up to 20% when using high doses. The doses prescribed by endochronologists to treat various problems are, in any case, quite low and should not have any adverse effects on the cardiovascular system, but they can occur among high-performance athletes, who use much higher doses.
4. Negative effects on natural testosterone production:
Using testosterone propionate, even in small doses, will bring with it the decrease of the body's natural testosterone production. This is not necessarily a bad thing, the body simply ceases to produce testosterone, given that you exogenously administer what it should produce alone. Our body is very intelligent, if it feels that there is no need to do something, it will not. For those of you who suffer from low natural testosterone production this should not be a problem, as your body could not produce the testosterone it needs alone, cessation of production is not a problem, as testosterone treatment is the most many times, in life, for those who suffer from these problems.
In the case of performance athletes, if you want to start your own testosterone production, we must follow a post-cycle therapy, containing the necessary drugs, generally being clomid and tamoxifen (for a testosterone propionate cycle). However, these can vary if we add other steroids to this cycle. It is good to mention that the cessation of the natural production of testosterone will lead to a decrease in the size of the testicles.
Testosterone propionate is not hepatotoxic, it will not put stress on the liver.
Administration of testosterone propionate:
For patients with low testosterone levels, 25-50 mg 2-3 times a week should be given.
For performance athletes, doses of over 50-100 mg daily are used.
Propionate testosterone can be used alongside any other steroid, most users choosing to combine it with masteron, trenbolone or winstrol.
Where is the propionate testosterone injected ?
It can be injected into any muscle group. For those who administer doses too high in a single injection (over 2 ml), the injection will be sought in a larger group. Most people choose to inject testosterone propionate into the buttocks, quadriceps, shoulders, or even triceps.