ANAPOLON 50mg - ABDI IBRAHIM
Anapolon (also known as Oxymetholone and Anadrol) is a synthetic anabolic steroid developed in 1960 by Syntex Pharmaceuticals. Initially, Anapolon was developed as a drug for osteoporosis and anemia treatment, as well as to stimulate muscle growth in malnourished and debilitated patients. Oxymetholone was approved by the FDA for use in humans. Later non-steroidal drugs which effectively treated anemia and osteoporosis, due to which the popularity of Anapolon fell and by 1993 Syntex decided to stop production of the drug as well as many other manufacturers did. However, oxymetholone still remained in medicine, as new research has shown that Anapolon is effective in the treatment of HIV-infected patients.
Anapolon (manufactured by Abdi İbrahim) is available in tablets of 50 mg and it is one of the most powerful androgenic steroids.
- Severe muscle growth (oxymetholone is considered one of the most effective steroids in bodybuilding for muscle gain – up to 15 kg of muscle mass for 1 cycle)
- A significant increase in strength
- Anapolon eliminates joint pain in some athletes, improves its function (due to higher output of synovial fluid, caused partly by progestin nature).
- Anapolon helps to burn body fat; best results can be obtained in the abdominal area. It means that the "oxy" can be used as a fat burning agent by those men who are experiencing problems with losing belly fat.
- It reduces the sex hormone-binding globulin, it makes the effect of other anabolic hormones.
- It increases the amount of red blood cells, increases stamina.
Enough for a long time it was thought that the most of weight gain achieved using oxymetholone falls is because of water. At the same time, since the middle of the last decade, professional bodybuilders have begun to actively use oxymetholone in precompetitive preparation. Now, its administration is not limited to only one or two days before the start - "oxy" is actively used throughout the period of preparation for a competition; and water retention doesn’t occur.
Researchers from the University of Southern California decided to thoroughly understand what oxymetholone is and what can be expected from it. As subjects of the study they selected men aged 65-80 years - this choice would most clearly emphasize the dignity of the drug and eliminate the influence of external factors (all subjects had the level of testosterone below normal). Another important point: the subjects were not engaged in any training session (and so one-sided factor was excluded). Protein intake was 1 g per kg of its own weight.
Cycle results: Those who took 50 mg of oxymetholone per day, gained on average 3.3 kg for a total weight of 12 weeks. The increase in those who took 100 mg per day was 4.2 kg. The subjects did not take extra protein and were not exercising.
Not only the total weight changed, but also the body composition. So subjects lost fat, particularly in the abdominal area, the increase of muscle tissue was even more pronounced. In the first group average adipose tissue loss was 2.6 kg and in the second - 2.5 kg. It is interesting that second group lost more weight in the abdominal area (2.2 kg vs. 1.7 kg) without training.
17-alpha-alkyl group in the structure of the drug allows to bypass the liver without being destroyed, but it makes hepatotoxic. The were studies, where subjects used 50 mg of Oxymetholone per day during 30 weeks. The result revealed various side effects, including hepatotoxicity.
During the Schroeder’s survey in 2003, subjects were receiving a dose of 50 or 100 mg / day, and only one of them significantly improved continuous reception of ALT (alanine aminotransferase) during 12 weeks. But, as it turned out, it was associated with alcohol use before the blood donation. Repeated analysis of ALT didn’t show any increase. All other subjects had ALT and AST slightly increased, but it always remained within the normal range. So, the toxic effect on the liver is largely exaggerated. Most secure dosage is 50 mg per day (or less).
It should also be noted that oxymetholone does not convert into estrogen, it can nevertheless often cause water retention, gynecomastia, increase blood pressure and others. Note that oxymetholone has a relatively low progestin activity (compared with progestins: Nandrolone and Trenbolone). Therefore, in the extreme case it is recommended to use prolactin blockers.
In some cases, (when using large doses), the drug can cause diarrhea, impair appetite, cause mild nausea. Oxymetholone suppresses the production of testosterone less than most steroids.
The Anapolon cycle is best for men over 21 years for intensive muscle mass gains. The duration of oxymetholone cycle is 4 -6 weeks. Do not make it longer than 6 weeks, firstly because the greatest results are observed during the first three weeks, and secondly, because of the possible hepatotoxicity.
The maximum tolerated dose of Anapolon is 100 mg per day. Firstly, because it has been proven that a greater increase in dosage does not lead to the best results. Secondly, the risk of side effects increases. The optimal dose for beginners is 50 mg per day. Intake of the steroid with a gradual increase in dosage is meaningful only in the case when there are concerns about its tolerance. Usually intake occurs in a stable dosage from the first to the last day of the cycle. Gradual tapering of the dosage does not make sense.
Upon completion of the cycle, PCT is required. Start taking Testosterone boosters and estrogen blockers (clomiphene, toremifene, don’t take tamoxifen because since it stimulates the progestin receptors) for 3-4 weeks, to restore natural testosterone. To maximize the effectiveness of the cycle, take a complex of Sports nutrition for muscle mass gain and follow a diet for muscle mass gain.
Be sure to consult a specialist before taking oxymetholone.
Oxymetholone is well combined with certain injectable drugs, but do not combine it with the 17-alpha-alkylated steroids, since it will increase the hepatotoxicity. Anapolon often used for so-called "fast start" (anabolic effect begins to manifest itself very quickly), providing significant increase in strength and body weight in the very early stages of the cycle, while the other drugs in the stack gradually increase the concentration. The combination allows to achieve the best effect, due to the fact that oxymetholone reduces the concentration of sex hormone binding globulin, increasing the free fraction of other hormones, while it is synergist for a very large number of drugs. Anapolon has a low affinity for androgen receptors (bad contacts them) other high-androgenic hormones can provide a full effect through interaction with these receptors without competing with Anapolon. For muscle mass gain, Anapolon is combined with testosterone, Boldenone, Primobolan, but not with Nandrolone and Trenbolone, because it can lead to a more pronounced progestin effect.
To increase the power performance, it is most often used with various esters of testosterone. A very effective combination is the combination of Oxymetholone with a suspension of stanozolol. Athletes note a rapid increase in strength. But it is necessary to take into account the high risk of injury of this *combination, especially for people with chronic injuries.
For cutting, oxymetholone is hardly used due to its property to provoke a strong water retention. Bodybuilders of competitive level often use a one-time receipt of 100-250 mg of oxymetholone on the day of going on the stage. It gives fullness of athlete’s muscles.