Sustanon 250 is an injection medicine that contains testosterone. Testosterone is the main endogenous hormone, irreplaceable for the growth and normal development of male genitalia and secondary male sexual characteristics. During the life of adult men, testosterone is indispensable for the functioning of the testicles and accompanying structures, as well as for maintaining libido, well-being, erectile potency and for the function of the prostate gland and seminal vesicles.
Treatment of hypogonadal men with Sustanon 250 results in a clinically significant increase in plasma testosterone, dihydrotestosterone, estradiol and androstenedion, as well as decreased levels of SHBG (globulin binding sex hormones). Luteinizing hormone (LT) and follicle stimulating hormone (FSH) levels are restored to normal.
Treatment with the drug Sustanon 250 leads to a reduction in the symptoms of testosterone deficiency. In addition, the mineral density of bones and muscle mass increases, in obese patients, weight loss occurs. During treatment, sexual functions are normalized, including erectile function and libido.
When the drug is used, serum concentrations of HDL (high density lipoprotein), low density lipoprotein (LDL) and triglycerides are low, hemoglobin and hematocrit concentrations are increased, but there is no clinically significant change in liver enzyme level and PSA ( prostate specific antigen). The drug can cause an enlargement of the prostate size without any functional changes observed.
In boys with delayed growth and puberty, androgen use accelerates growth, stimulates the development of secondary sexual characteristics.
Treatment of transgender women with androgens, such as Sustanon 250, promotes masculinization.
Sustanon 250 contains a number of testosterone esters with a different duration of action. These ethers, after entering the circulating blood, are immediately hydrolyzed into the natural testosterone hormone.
A single dose of Sustanon 250 results in an increase in total plasma testosterone, whose Cmax reaches approximately 70 nmol / L and is observed approximately 24-48 hours after administration. In men, testosterone levels return to the lower limit of the norm in about 21 days.
In vitro assays showed a high degree of nonspecific binding to testosterone plasma proteins (more than 97%) and to SHBG.
Testosterone is metabolized to dihydrotestosterone and estriol naturally.
The drug is mainly excreted in the urine as androsterone conjugates.
Issuance form of Sustanon 250:
Solution for the introduction of yellow IM.
The active substances are: testosterone propionate (30 mg), testosterone phenylpropionate (60 mg), testosterone isocaproat (60 mg), testosterone decanoate (100 mg).
The total testosterone content is 176 mg / ml.
Auxiliary substances: peanut oil, benzyl alcohol, nitrogen.
The drug Sustanon 250 should be given in-depth IM.
The dosage regimen, as a rule, depends on the individual response of the patient to the treatment.
Usually, the dose is 1 ml every 3 weeks.
Overdose with Sustanon 250:
The acute toxicity of Sustanon 250 in the administration of IM is very low. Priapism in men is a symptom of chronic overdose. In the case of priapism, the treatment with Sustanon 250 should be stopped temporarily and after the disappearance of this symptom it will resume at lower doses.
Interaction with Sustanon 250:
Drugs that induce or inhibit enzymes can consequently reduce or increase testosterone concentration. Therefore, it may be necessary to adjust the dose and / or the interval between injections.
Androgens can increase glucose tolerance and reduce the need for insulin or other hypoglycemic drugs in people with diabetes.
High doses of androgens may increase the action of coumarin-type anticoagulants, which may reduce the doses of these drugs.
Side effects of Sustanon 250:
Usually, high-dose androgen treatment, with prolonged treatment and / or frequent administration, is associated with the following undesirable reactions:
prostate cancer (or worsening course of diagnosed prostate cancer)
fluid retention (edema)
depression, increased nervous excitability, mood changes, increased or decreased libido.
blood pressure rise
gynecomastia, oligospermia, low ejaculation volume, priapism, functional disorders of the prostate (hypertrophy).
liver dysfunction, decreased levels of LDL, HDL and serum triglycerides, increased PSA level, hypercalcemia
Sustanon 250 is a medicine that contains testosterone substitution and is indicated in men with pathological disorders associated with primary and secondary hypogonadism, both congenital and acquired.
Contraindications Sustanon 250
Sustanon 250 is contraindicated in case of:
prostate or breast cancer (established or suspected);
hypersensitivity to any component of the drug;
children under 3 years (in relation to benzyl alcohol content)