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News from the anabolic world
An article that goes a little into the underground world of substances used by athletes. More specifically, we will talk about the latest discoveries regarding growth hormone and deca-durabolin.
Human growth hormone is required for IGF-1 to exert its action
Human growth hormone (HGH) is a basic anabolic hormone in the human body. It helps in the development of bones and muscles, but also influences metabolism and fat deposits. But most of the anabolic effect exerted by this hormone is mediated by IGF-1 (insulin-like growth factor-1). This is another key hormone in the body, produced in the liver and other tissues as a result of stimuli given by the human growth hormone. This knowledge led to the development of a model for understanding the direct and indirect actions of growth hormone. The direct effects of growth hormone, such as changes in metabolism and fat deposits, do not require IGF-1. These effects occur as a result of the interaction of the proteins from which the growth hormone is formed with the specific receptors. Indirect, anabolic (tissue growth) effects require IGF-1. But are things so simple? A study in the Journal of Bone Mineral Research suggests that no.
The study examined the effects of IGF-1 administration in a group of mice suffering from functional mutations of growth hormone receptors. Basically, these animals are raised to be resistant to growth hormone. But the same mice were also raised with mutations in the hepatic production of IGF-1. These mice produced large amounts of IGF-1 in the absence of growth hormone; the purpose was to observe and isolate the effects of IGF-1 on skeletal muscle and metabolism. The result was not the one expected, based on the direct and indirect effects model described above. High levels of IGF-1 in mice have improved metabolism and body fat levels, but have not been able to provide effective anabolic stimulation on muscles and bones. The mice suffered from osteoporosis. More work is needed to determine exactly what is needed and the growth hormone to perform these actions. The two hormones, HGH / IGF-1, may have synergistic effects, not separate.
Deca-durabolin heals bone fractures
Many people have fractured their bones over time. From children falling from trees to car accidents, contact sports, seniors falling on the ice, etc. We think of bills as a temporary discomfort, but they can have serious, long-term consequences. Healing a stuffed bone is a complex process. First the injured area becomes inflamed, then a callus forms and finally the callus and bone are remodeled, ideally to the initial shape and strength. But often this healing process does not go to the end. Especially in the elderly, side effects occur, especially the lack of mobility and pain. That is why the medical world is seeking new therapies to speed up the healing of fractures. It seems that among the most effective such therapies is the use of decades-old drugs, such as anabolic steroid and androgen Deca-durabolin.
A paper published in 2013 in the Journal of Clinical and Diagnostic Research examined the effect of Deca-durabolin (nandrolone decanoate) on bone fracture healing. The experiment involved rabbits, who were anesthetized and then fractured. The group of rabbits that received Deca-durabolin had a significantly higher fracture healing rate. The process was also characterized by a more accentuated formation of calluses. Osteoblastic activity, as measured by local concentrations of alkaline phosphates, was also greatly increased. And catabolic activity in the bones (a process called bone resorption) was reduced. Analyzing the fracture points of the bones, the calluses were denser in the animals that received nandrolone and the spaces between the bones caused by better coverage. The researchers concluded that anabolic steroids such as Deca-durabolin can help heal bone fractures but also reduce the negative health effects of these fractures.
Intranasal growth hormone
Human growth hormone (HGH) is a difficult drug to administer. What I mean is that it can be difficult to bring into the body. The drug itself (somatotropin) is a long and complex chain of amino acids. It is too large to pass through the skin if administered as a gel. At the same time it is too delicate to be administered orally. The growth hormone molecule would be destroyed in the intestines long before it is absorbed into the bloodstream. So far the only viable method of HGH administration is injections. But things can change. Researchers in the UK are testing a new HGH-based product that uses a nasal administration system called CriticalSorb. If approved, it will be the first successful alternative to HGH injections.
Clinical tests were performed, in which the traditional method of administration was compared with CriticalSorb. It seems that so far the results are encouraging. So far, two Phase I clinical trials have been completed using CriticalSorb and HGH. Bioavailability is lower for nasal spray but this can be offset by increasing the dose. The effects of the tests led to the increase of IGF-1 in the blood, similar to the traditional administration by injections.